Celgene Principal Scientist, Pharmacology (Pre-Clinical) in Cambridge, Massachusetts


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


The Principal Scientist, Pharmacology will provide scientific support to the discovery organization by providing knowledge and experience in in vivo proof of principle support and biomarker selection for small molecule target validation, specifically in the immunology/inflammation disease area. The pharmacologist will provide guidance and expertise as an integral member of discovery teams, and will assure a quality product delivery for team decision making. This role includes both a bench presence and project team representation, and will require that the candidate can navigate both of these responsibilities.

The pharmacologist will also be required to identify outsourcing facilities (CROs) to facilitate in vivo pharmacology that is an area of that CRO’s expertise. The pharmacologist will need to communicate timing, budget and monitor the study conduct, as appropriate.

Responsibilities will include, but are not limited to, the following:

Knowledge of and direct experience with models of inflammatory disease (IBD, psoriasis, arthritis/spondylitis) and endpoints/drives of disease in rodent models. Serve as a Principal Investigator on IACUC protocols. Able to draft protocols and present clearly to IACUC committee. Participates as a representative of preclinical sciences to discovery teams to provide expertise and knowledge from the pharmacology discipline. Ability to provide mentorship and guidance to other scientists in the preclinical group, with regard to model characterization, biomarkers, points to consider, and limitations of rodent models of disease. Ability to define a workplan to enable progression of targets toward candidate nomination, including evaluations of secondary pharmacology, and requirements for pharmacology data package for IND authorship.

Skills/Knowledge Required:

  • PhD in Pharmacology, Animal Science, or a related biological discipline with at least 8 years relevant pharmaceutical R&D experience. Previous experience with design and execution of preclinical pharmacology studies, particularly in immunology, to support multiple indications in inflammatory diseases is required. Knowledge of incorporation of relevant biomarkers in preclinical proof of concept studies is required. Previous experience managing internal and externally conducted studies and monitoring study conduct and reporting is highly desired.

  • Solid understand of immunology discovery research, focused primarily on in vivo and ex vivo evaluations of small molecules targeted to immune/inflammatory disease targets.

  • Ability to provide expertise and guidance to discovery project teams with regard to animal models of disease and relevant PK/PD and biomarker assessments. Knowledge of the literature and current science in pharmacology assessments

  • Knowledge of basic pharmacokinetics

  • Ability to generate high quality data in a dynamic high paced environment

  • Knowledge of outsourcing CROs and monitoring of studies at outsourced sites

  • Experience in in vivo study conduct

  • Ability to generate protocols, and record data in a notebook (electronic or hardcopy)

  • Ability to build a pharmacology package that will enable INDs for nominated molecules.

Skills/Knowledge Desired:

• Knowledge of immunology/inflammation• Knowledge of in vitro assessment of pharmacologic activity

Personal characteristics

  • Strong presence as well as sense of urgency and priorities as well as flexibility. The ability and strong desire to "make things happen".

  • Decisive as well as collaborative.

  • High level of honesty and integrity.

  • Excellent interpersonal skills with particular emphasis on communication & relationship building.

  • Motivated to be part of an organization that aims to make a difference through cutting edge research.

  • Passion for the pharmaceutical industry.


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.