Celgene Director, Protein Homeostasis / Drug Discovery in San Diego, California


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Protein Homeostasis at Celgene

The PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.


We seek an experienced drug-hunter with a proven track record of success. Candidates will be highly motivated and accomplished life scientists or medicinal chemists with experience in the pharma / biotech sectors. The successful candidate will lead an early drug discovery team and manage matrixed project teams charged with delivering drug candidates. She/he will contribute to a variety of programs by setting strategies, priorities, and driving critical path drug discovery objectives. Candidates with oncology industry experience and demonstrated record of drug discovery required. Knowledge in E3 ligase and UPS biology and chemistry a plus.

Responsibilities will include, but are not limited to, the following:

  • Collaborate, motivate, and mentor matrixed teams empowered to implement protein homeostasis TCoE discovery programs from target identification to development candidate nomination. An emphasis in biology / chemistry data integration, setting strategies, and “big picture” thinking is key.

  • Lead a team of 8 Scientists and Research Associates engaged in target and drug discovery efforts focused on identifying new therapies for cancer treatment.

  • Effectively collaborate with a fully integrated multidisciplinary team comprised of both internal and external resources to facilitate the success of projects.

  • Evaluate and implement novel and emerging technologies to advance drug discovery effort.

  • Regular communication with Senior Management around portfolio progression, strategy, and goal setting ensuring scientific excellence and rigor.

  • Provide direction and lead the execution of multiple projects, including program design, assay development, in-vitro proof-of-concept, and in vivo translational studies.

  • Excellent leadership capabilities with at least five years of experience guiding and motivating successful teams, as well as building and managing productive research collaborations.

Experience/Knowledge/Skills Required:

  • Ph.D. with at least 12 years of drug discovery experience and 5 years of management and successful project leadership experience.

  • Significant oncology experience and managing Ph.D level reports required.

  • Excellent experimental design, troubleshooting, and data analysis skills.

  • Demonstrate strong analytical skills

  • Ability to work well as an individual and in a team environment

  • Strong verbal and written communication skills

  • Very strong communication and partnering skills.

Functional/Scientific/Technical Skills:

  • Able to design complex experiments with scientific rationale.

  • Able to critically analyze and interpret biology and chemistry data.

  • Understands fundamental scientific problems and can apply knowledge to research and development projects and problems in a positive manner.


  • Works as an individual contributor or mentor

  • Viewed as a knowledgeable resource within R&ED

  • Supervising/mentor role in function; decides deployment of resources and goal setting

Creativity and Problem Solving:

  • Critically assess project(s) and formulates ideas

  • Implement solutions independently and within the project team

  • Mentors strategy and critical path objections

Teamwork and Influence:

  • Communicates with cross functional teams and beyond PH TCoE

  • Routinely contributes to the achievement of workgroup/team goals

  • Represents department on multi-disciplinary or cross functional teams

Organizational Impact:

  • Direct impact on R&ED performance and development candidate nominations

  • Impact achieved by contributing/mentoring team efforts and creating novel science driven discovery strategies



Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.