Celgene Associate Scientist - Immuno Oncology in Seattle, Washington

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Candidate will join the Immuno-Oncology Biology Group in Seattle, and report to a Sr. Principal Scientist.

The candidate will be an experienced, self-motivated, and resourceful researcher to join a team focused on the discovery and characterization of novel drug candidates that modulate immune system for the treatment of cancer. Candidates should have a deep understanding of cellular immunology, and/or immuno-oncology. Extensive laboratory experience with development and implementation of in vitro immunological assays for evaluating activity and mechanism of action of immuno-oncology drug candidates.

The successful candidate will be an independent contributor and work directly with corporate partners, cross-functional teams and project teams to support pre-clinical programs.

Responsibilities:

  • Actively participate in the development and implementation of immune cell assays for drug candidate evaluation, mechanistic studies, and biomarker development.

  • Perform cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte activation and cytotoxicity assays, multi-parameter flow cytometry, ELISA, ELISpot, RNA preparation, RT-PCR , viral transduction, mammalian cell transfection and western blotting

  • Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail, conduct analysis and report results

  • Independently develop and follow protocols and function with minimal supervision

  • Contribute to design of experimental procedures and search literature for targeted information.

  • Interact with manager and project team to review data and plan next steps

  • Record experimental details and maintain laboratory notebook

  • Cultivate positive and productive working relationships with colleagues

  • Prepare and present work at group meetings

  • Participate in maintenance of routine laboratory instrumentation and supplies

  • Use instrumentation to perform basic experiments

  • Flexible to changing priorities

  • Respectful of laboratory safety policies and practices

  • May supervise other Research Associates as needed

Qualifications

Prerequisites:

  • Completed BS in Immunology (or relevant discipline) and minimum of 8+ years of pharmaceutical laboratory experience required; or

  • Completed MS in Immunology (or relevant discipline) and minimum of 6+ years of pharmaceutical laboratory experience required; or

  • Familiarity with and experience in the drug development process from discovery through IND filing in an industry setting

  • Ability to multitask, independently organize time and plan specifics of work

  • Excellent communication and interpersonal skills demonstrated in a team environment

Skills/Knowledge Required:

  • A strong team player that brings people along through a supportive, engaged and creative way of working

  • Solid understanding of scientific mechanisms and experimental techniques, with knowledge of immunology and cancer cell biology preferable

  • Extensive experience in performing primary immune cell assays using key immune cell populations: T cells, Tregs, NK cells, DC, macrophage and understanding immunologic pathways

  • Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, Incucyte etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, microscopy), and molecular biology (expression analysis and gene silencing) techniques

  • Familiarity with techniques related to biomarker research and development

  • Extensive hands-on laboratory experience in developing and using state-of-the-art molecular and cell biology tools to identify and validate novel drugs candidates in primary human immune cells

  • Proven track record in working in effective cross site multi-functional teams

  • Ability to work independently but also in a collaborative manner with local and cross site teams

  • Experience in working with CROs to effectively outsource research and development needs.

  • Excellent communication and presentation skills.

  • Leader that will inspire and engage staff and colleagues across R&D

  • Creative, innovative and inquisitive personality

  • Good collaboration and communication skills.

#LI-POST

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.