Celgene Research Associate, Biology - Immuno-Oncology in Seattle, Washington
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
Celgene is looking for a highly motivated and dynamic individual to join the Immuno-Oncology Biology Group in Seattle. The individual will perform experiments to help discover and characterize novel therapeutics to enhance the immune system for the treatment of cancer. The successful candidate will have a proven technical and scientific track record and experience working in a multi-disciplinary team environment.
Responsibilities will include but are not limited to:
Independently plan, design, execute, interpret, troubleshoot and report on scientific experiments to enable timely decisions on therapeutic development activities from discovery through clinical.
Work at the bench to develop and execute established and novel in vitro and ex vivo immune cell and tumor cell assays for target validation, drug candidate evaluation, mechanistic studies and biomarker development.
Perform cell biology, molecular biology, and biochemical techniques including primary and tumor cell culture, lymphocyte and myeloid cell activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting.
Keep up with latest technological and scientific approaches to Immuno-Oncology research using literature and other sources.
Collaborate effectively and cultivate positive and productive relationships with other scientists within and outside Celgene.
Present to manager, project team and work groups, provide scientifically rigorous review of data and help plan next steps.
Contribute to written invention disclosures, internal and external regulatory reports as needed.
Understand drug development process and role within Celgene.
Participate in maintenance of routine laboratory instrumentation and supplies
Flexible to changing priorities
Adherence to laboratory safety policies and practices
May supervise other research associates as needed.
Bachelor’s degree in a scientific discipline with at least 4 years work experience or Master’s degree with at least 2 years work experience in relevant field of research.
Functional / Technical/ Scientific Skills and Knowledge Required:
Planning skills to execute on multiple work streams and provide timely and prioritized results Trouble shooting and problem solving skills to resolve technical and scientific questions in a multi-disciplinary, multi-site team oriented environment. Excellent communication skills working in a team focused multi-site environment. Good understanding of immunology and oncology. Familiarity with multiple parts of drug development process from validation through to early clinical studies. Technical experience with and scientific understanding of:
A subset of in vitro T cell, NK cell, macrophage, DC, Treg, tumor cell assays and relevant immunological pathways – myeloid cell and T cell assay experience preferred.
A subset of flow cytometry (FACS), cytotoxicity assays, ELISA, ELISpot, microscopy, Luminex, transfection, lentiviral infection, microscopy, RNA and protein purification and analysis (Taqman and western blot)
In vivo model and ex vivo assay knowledge and experience an advantage.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.